Resveratrol inhibits pancreatic cancer proliferation and metastasis by depleting senescent tumor-associated fibroblasts

Figure 6 Resveratrol inhibits pancreatic cancer cell proliferation and metastasis. A: Resveratrol effectively suppressed the proliferation of PANC-1 cells by inhibiting senescence in cancer-associated fibroblasts (CAFs); B: Resveratrol suppressed SW-1990 cell proliferation by inhibiting CAF senescence; C: The migratory ability of PANC-1 cells was inhibited by resveratrol; D: Resveratrol inhibited the migration of SW-1990 cells; E: Resveratrol inhibited the invasion of PANC-1 cells; F: Resveratrol inhibited the invasion of SW-1990 cells; G and H: After resveratrol intervention, there was evidence of epithelial-mesenchymal transition induction in pancreatic cancer cells. The scale bar represents 20 µm. ^aP < 0.05, ^bP < 0.01.