Resveratrol inhibits pancreatic cancer proliferation and metastasis by depleting senescent tumor-associated fibroblasts

Figure 4 Resveratrol inhibits senescence in cancer-associated fibroblasts. A: Resveratrol treatment resulted in the elimination of senescent cancer-associated fibroblasts; B-D: The expression of p21 and p16 was suppressed by resveratrol; E: Resveratrol intervention led to the restoration of Lamin B1 expression; F-M: There was a significant decrease in the expression of senescence-associated secretory phenotype factors. The scale bar represents 20 µm. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001.