Network pharmacology study and in vitro experimental validation of Xiaojianzhong decoction against gastric cancer

Figure 2 Targets of Xiaojianzhong decoction active ingredients and differentially expressed genes in gastric cancer. A: All genes related to gastric cancer and the number of targets of Xiaojianzhong decoction (XJZ) active ingredients; B: Volcano plot of differentially expressed genes identified based on GSE118916. Green represents down-regulated genes, red represents up-regulated genes, and gray indicates non-differentially expressed genes; C: Heatmap of intersecting targets. Blue and pink represent the normal group and tumor group, respectively; D: Intersection of up- and down-regulated genes associated with GC and targets of XJZ. Yellow represents the targets of the compound, and red and green represent the up- and down-regulated genes, respectively; E: LogFC values of the top 8 up- and down-regulated genes in the intersection targets, where red and green represent up- and down-regulated genes, respectively; F: Intersection plot of XJZ and gastric cancer (GC) targets. Blue areas represent GC targets and yellow areas represent XJZ targets. XJZ: Xiaojianzhong decoction; GC: Gastric cancer.