Inflammation-related markers and prognosis of alpha-fetoprotein producing gastric cancer

Figure 4 Analysis of the relationship between these inflammatory indicators as continuous variables and death. A: Restricted cubic spline (RCS) of six inflammation-related peripheral blood markers. The orange numbers were the corresponding values of each inflammatory indicator when hazard ratio equaled 1; B: Generalized additive mixed model (GAMMs) of six inflammation-related peripheral blood markers in survival group and death group. The RCS and GAMMs corrected age, sex, tumor location, tumor size, differentiation, lymphatic metastasis, liver metastasis, extrhepatic metastasis, time of liver metastasis, tumor-node-metastasis stage, T stage, N stage, vascular invasion and nerve invasion. In figure B, “0”, “1” and “P_int” referred to “survival group”, “death group” and “P_interaction”, respectively. AFP: Alpha-fetoprotein; GC: Gastric cancer; PNI: Prognostic nutritional index; ROC: Receiver operating characteristic; SII: Systemic immune-inflammation index; SIRI: Systemic inflammation response index.