Erythropoietin-induced hepatocyte receptor A2 regulates effect of pyroptosis on gastrointestinal colorectal cancer occurrence and metastasis resistance

Figure 3 Analysis of signal transduction pathways related to erythropoietin-induced hepatocyte receptor A2 and pyroptosis. Created by the BioRender. A: Pathogen-associated molecular patterns and damage-associated molecular patterns; B: Gram-negative bacteria; C: Chemo-drugs; D: Channle formation. PAMPs: Pathogen-associated molecular patterns; DAMPs: Damage-associated molecular patterns; HMGB1: High mobility group box 1; NLRP: NOD-like receptor protein; ASC: Apoptosis-associated speck-like protein containing a caspase recruitment domain; IL: Interleukin; GSDMD: Gasdermin D; LDH: Lactate dehydrogenase; MOMP: Mitochondrial outer membrane permeabilization; TNF: Tumor necrosis factor; PD-L1: Programmed death-ligand 1.