Impact of preoperative inflammatory and nutritional markers on the prognosis of patients with peritoneal metastasis of colorectal cancer

Table 3 Cox univariate and multivariate analyses of the 133 patients with peritoneal metastases of colorectal cancer

Variables	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Sex (female)	0.89 (0.56-1.41)	0.621
Age (≤ 60)	0.55 (0.35-0.84)	0.006	0.63 (0.39-1.01)	0.050
CEA (≥ 5.0 ng/mL)	0.88 (0.73-1.75)	0.570
CA199 (≥ 37.0 U/mL)	1.71 (1.11-2.61)	0.014	1. 19 (0.74-1.91)	0.450
CA125 (≥ 35.0 U/mL)	1.07 (0.69-1.65)	0.769
BMI (< 18.5 kg/m2)	1.22 (0.88-1.62)	0.356
Location (right side)	0.94 (0.64-1.38)	0.756
NLR (≥ 3.1)	2.02 (1.28-3.19)	0.002	1.81 (1.13-2.89)	0.010
Hb (normal)	0.47 (0.31-0.72)	< 0.001	0.65 (0.39-1.07)	0.080
Albumin (< 35 g/L)	2.11 (1.37-3.51)	< 0.001	1.25 (0.72-2.17)	0.420
Category (T4)	1.04 (0.68-1.59)	0.854
Category (N2)	1.02 (0.79-1.21)	0.857
Histology (mucinous adenocarcinoma and signet-ring cell carcinoma)	1.46 (0.94-2.27)	0.090
PCI (≥ 20)	1.91 (1.24-2.93)	0.003	1.92 (1.21-3.07)	0.006

HR: Hazard ratio; CI: Confidence interval; CEA: Carcinoembryonic antigen; CA199: Carbohydrate antigen 199; CA125: Carbohydrate antigen 125; BMI: Body mass index; NLR: Neutrophil-to-lymphocyte ratio; Hb: Hemoglobin; PCI: Peritoneal cancer index.