Streptococcus anginosus in the development and treatment of precancerous lesions of gastric cancer

Table 2 Studies on various systems of Streptococcus anginosus

Primary site	Developing diseases	Mechanism of action	Subsequent effect	Ref.
Oral	Periodontal abscess	Production of bacteriocins enhances membrane permeability, inhibits the growth of associated species, promotes the development of chronic inflammation and abscesses	Dental periapical abscesses	Fisher and Russell[77]
			OIs	Furuholm et al[78]
Respiratory tract	Lung abscess	Inhalation of oral secretions, direct trauma or surgical bedding, adjacent extension, and hematogenous dissemination	Parapneumonic empyema	Gonzalez et al[79]
Esophagus	Esophageal cancer	Correlated with GrzB+ and CD8+T-cell infiltration in tumor tissues	Esophageal squamous cell carcinoma; Barrett's esophagus	Lv et al[80]
				Wu et al[81]
Stomach	Gastric cancer	Spontaneously induced chronic inflammation, atrophy, mucus chemotaxis, and heterogeneous hyperplasia of the gastric mucosa	PLGC	Yang[7]
				Zhou et al[82]
Intestinal tract	Colorectal cancer	Loss of integrity of the blood mucosal barrier forms pus-filled and infected	Adenocarcinoma of the colon	Rawla et al[83]
Liver	Liver abscess	Causes localized suppurative inflammation destroying hepatocytes and surrounding tissues	PLA	Pilarczyk-Zurek et al[55]
				Morii et al[84]
Genitourinary tract	Genitourinary infections	Invades the bloodstream following urinary tract infections; causes lysis of vaginal epithelial cells	Urinary tract infection	Wu and Zheng[85]
			Aerobic vaginitis	Tao et al[86]
Hearts	Pericarditis, endocarditis	Hematogenous dissemination from distant organs	Bacterial pericarditis; infective endocarditis	Finn et al[87]
Cerebrum	Brain abscess, meningitis	Continuous venous dissemination or hematogenous dissemination from a distant site; invasive pyogenic infection	Subdural hemorrhage	Esplin et al[88]
			Intracranial subdural abscess; hydrocephalus	Sakurai et al[89]

OIs: Odontogenic infections; PLGC: Precancerous lesions of gastric cancer; PLA: Pyogenic liver abscess.