Insulin-like growth factor 2 targets IGF1R signaling transduction to facilitate metastasis and imatinib resistance in gastrointestinal stromal tumors

Figure 5 Insulin-like growth factor 2/IGF1R regulates imatinib resistance of gastrointestinal stromal tumors by regulating glycolysis. A: Tumor growth in xenografted nude mice; B: Tumor volumes in sh-insulin-like growth factor 2 (IGF2)-gastrointestinal stromal tumors (GIST)-T1 mouse xenograft models treated with imatinib; C: After 35 d, the mice were killed and the tumors were weighed; D: Assay of IGF1R, p-IGF1R, PI3K, AKT, and p-AKT in tumor tissue by western blotting; E: Assay of drug sensitivity in OE-IGF2-GIST882 and GIST-T1 cells treated with 2-deoxy-D-glucose (2-DG); F: Flow cytometry assay of apoptosis of OE-IGF2-GIST882 and GIST-T1 cells treated with 2-DG. Data are mean ± standard deviation. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001.