Insulin-like growth factor 2 targets IGF1R signaling transduction to facilitate metastasis and imatinib resistance in gastrointestinal stromal tumors

Figure 1 High expression of insulin-like growth factor 2 in gastrointestinal stromal tumors with liver metastasis and closely related to drug resistance. A: Differentially expressed genes in gastrointestinal stromal tumors (GIST) with liver metastasis tissues and normal gastric tissues (|log2FC| > 1; P < 0.05); B: Differentially expressed genes in imatinib sensitive and in seven Imatinib-resistant GIST patients (|log2FC| > 1; P < 0.05); C: Western blot assay of insulin-like growth factor 2 (IGF2) protein expression in GIST cell lines (GIST882, GIST882-R, GIST-T1, GIST-T1-R); D: ELISA of IGF2 expression in GIST cell lines (GIST882, GIST882-R, GIST-T1, GIST-T1-R). Data are mean ± standard deviation. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001.