Expression and significant roles of the long non-coding RNA CASC19/miR-491-5p/HMGA2 axis in the development of gastric cancer

Figure 3 The role of HMGA2 in gastric cancer. A: The targeting relationship between miR-491-5p and HMGA2 by the dual luciferase reporter experiment; B: The expression of HMGA2 affected by miR-491-5p mimics and miR-491-5p inhibitor through reverse transcription polymerase chain reaction; C: The immunohistochemical staining of cancer and adjacent tissue; D: The effect of HMGA2 on cell proliferation was detected by cell counting kit-8 assay; E: Flow cytometry was used to explore the regulation of HMGA2 about apoptosis. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001 was compared with the control group respectively. P < 0.05 was considered statistically significant.