Copyright
©The Author(s) 2024.
World J Gastrointest Oncol. Aug 15, 2024; 16(8): 3672-3686
Published online Aug 15, 2024. doi: 10.4251/wjgo.v16.i8.3672
Published online Aug 15, 2024. doi: 10.4251/wjgo.v16.i8.3672
League table | |||||||||
Any grade AEs | |||||||||
HAIC | 0.86 (0.47; 1.56) | 0.88 (0.35; 2.22) | 0.48 (0.25; 0.92) | 0.16 (0.05; 0.54) | |||||
0.86 (0.47; 1.56) | HAIC + Lenv | 0.76 (0.38; 1.55) | |||||||
0.88 (0.35; 2.22) | 1.03 (0.34; 3.09) | HAIC + A | |||||||
0.66 (0.26; 1.66) | 0.76 (0.38; 1.55) | 0.74 (0.20; 2.75) | HAIC + Lenv + A | ||||||
0.48 (0.25; 0.92) | 0.56 (0.23; 1.35) | 0.54 (0.18; 1.68) | 0.73 (0.24; 2.27) | Sora | 0.53 (0.22; 1.24) | ||||
0.25 (0.09; 0.74) | 0.29 (0.09; 1.00) | 0.29 (0.07; 1.18) | 0.38 (0.09; 1.59) | 0.53 (0.22; 1.24) | HAIC + Sora | ||||
0.16 (0.05; 0.54) | 0.19 (0.05; 0.72) | 0.19 (0.04; 0.84) | 0.25 (0.06; 1.13) | 0.34 (0.09; 1.33) | 0.65 (0.13; 3.23) | TACE | |||
3-4 grade AEs | |||||||||
HAIC + PD-1 | 0.26 (0.01; 6.54) | ||||||||
0.26 (0.01; 6.54) | HAIC | 0.96 (0.22; 4.26) | 0.63 (0.30; 1.31) | 0.49 (0.09; 2.69) | 0.32 (0.13; 0.75) | ||||
0.25 (0.01; 8.71) | 0.96 (0.22; 4.26) | HAIC + Lenv | 0.54 (0.05; 5.76) | ||||||
0.16 (0.01; 4.45) | 0.63 (0.30; 1.31) | 0.65 (0.12; 3.43) | Sora | 0.42 (0.14; 1.23) | |||||
0.13 (0.00; 9.57) | 0.52 (0.03; 8.50) | 0.54 (0.05; 5.76) | 0.83 (0.05; 14.97) | HAIC + LENV + A | |||||
0.13 (0.00; 4.90) | 0.49 (0.09; 2.69) | 0.51 (0.05; 4.89) | 0.79 (0.12; 5.02) | 0.96 (0.04; 25.23) | HAIC + A | ||||
0.07 (0.00; 2.97) | 0.29 (0.05; 1.70) | 0.30 (0.03; 3.04) | 0.46 (0.07; 3.16) | 0.56 (0.02; 15.36) | 0.58 (0.05; 6.78) | HAIC + TACE | 1.10 (0.23; 5.19) | ||
0.08 (0.00; 2.32) | 0.32 (0.13; 0.75) | 0.33 (0.06; 1.84) | 0.51 (0.16; 1.59) | 0.61 (0.03; 11.50) | 0.64 (0.10; 4.30) | 1.10 (0.23; 5.19) | TACE | ||
0.07 (0.00; 2.21) | 0.26 (0.07; 0.97) | 0.27 (0.04; 1.97) | 0.42 (0.14; 1.23) | 0.51 (0.02; 11.17) | 0.53 (0.06; 4.51) | 0.91 (0.10; 8.28) | 0.83 (0.17; 3.97) | HAIC + Sora | |
3-4 grade AEs for thrombocytopenia | |||||||||
Sora | 0.27 (0.15; 0.46) | 0.19 (0.01; 4.08) | 0.11 (0.05; 0.24) | ||||||
0.85 (0.02; 29.67) | HAIC + TACE + S-1 | 0.36 (0.01; 8.96) | |||||||
0.30 (0.07; 1.37) | 0.36 (0.01; 8.96) | HAIC + TACE | 0.56 (0.20; 1.55) | ||||||
0.27 (0.15; 0.46) | 0.32 (0.01; 11.60) | 0.89 (0.18; 4.42) | HAIC + Sora | ||||||
0.24 (0.00; 14.92) | 0.28 (0.00; 58.91) | 0.78 (0.01; 56.14) | 0.88 (0.01; 57.66) | HAIC + Lenv | 0.47 (0.01; 27.94) | ||||
0.19 (0.01; 4.08) | 0.22 (0.00; 24.56) | 0.63 (0.02; 19.15) | 0.70 (0.03; 15.97) | 0.80 (0.00; 140.28) | HAIC + RT | ||||
0.17 (0.06; 0.52) | 0.20 (0.01; 5.89) | 0.56 (0.20; 1.55) | 0.63 (0.18; 2.20) | 0.72 (0.01; 46.14) | 0.90 (0.03; 23.63) | TACE | 0.66 (0.29; 1.47) | ||
0.08 (0.00; 4.22) | 0.09 (0.00; 17.21) | 0.25 (0.00; 15.93) | 0.29 (0.01; 16.31) | 0.33 (0.00; 94.05) | 0.41 (0.00; 63.25) | 0.45 (0.01; 24.96) | HAIC + A | 1.45 (0.03; 73.68) | |
0.11 (0.05; 0.24) | 0.13 (0.00; 4.24) | 0.37 (0.10; 1.35) | 0.42 (0.16; 1.07) | 0.47 (0.01; 27.94) | 0.59 (0.02; 14.00) | 0.66 (0.29; 1.47) | 1.45 (0.03; 73.68) | HAIC | 0.54 (0.03; 8.82) |
0.06 (0.00; 1.09) | 0.07 (0.00; 6.15) | 0.20 (0.01; 4.33) | 0.23 (0.01; 4.28) | 0.26 (0.00; 35.95) | 0.32 (0.00; 21.78) | 0.36 (0.02; 6.48) | 0.79 (0.01; 97.36) | 0.54 (0.03; 8.82) | HAIC + PD-1 |
3-4 grade AEs for elevated total bilirubin | |||||||||
HAIC + Lenv | 0.57 (0.01; 29.09) | 0.34 (0.03; 4.22) | |||||||
0.65 (0.02; 23.55) | HAIC + RT | 0.49 (0.04; 5.61) | |||||||
0.56 (0.01; 33.37) | 0.86 (0.01; 51.75) | HAIC + PD-1 | 0.60 (0.02; 14.98) | ||||||
0.57 (0.01; 29.09) | 0.87 (0.00; 178.10) | 1.01 (0.00; 293.95) | HAIC + LENV + A | ||||||
0.34 (0.03; 4.22) | 0.52 (0.04; 6.61) | 0.60 (0.02; 14.98) | 0.60 (0.01; 63.73) | HAIC | 0.94 (0.46; 1.89) | 0.23 (0.01; 5.65) | 0.24 (0.09; 0.65) | ||
0.32 (0.02; 4.68) | 0.49 (0.04; 6.06) | 0.57 (0.02; 16.06) | 0.56 (0.00; 65.61) | 0.94 (0.37; 2.38) | HAIC + Sora | 1.00 (0.54; 1.84) | |||
0.32 (0.02; 4.36) | 0.49 (0.04; 5.61) | 0.57 (0.02; 15.15) | 0.56 (0.00; 62.97) | 0.94 (0.46; 1.89) | 1.00 (0.54; 1.84) | Sora | |||
0.16 (0.01; 2.86) | 0.25 (0.01; 4.46) | 0.29 (0.01; 9.46) | 0.28 (0.00; 36.96) | 0.47 (0.12; 1.90) | 0.51 (0.10; 2.68) | 0.51 (0.11; 2.39) | HAIC + TACE | 0.50 (0.19; 1.30) | |
0.08 (0.00; 4.58) | 0.12 (0.00; 7.10) | 0.14 (0.00; 12.89) | 0.14 (0.00; 39.31) | 0.23 (0.01; 5.65) | 0.24 (0.01; 6.87) | 0.24 (0.01; 6.50) | 0.48 (0.01; 15.85) | HAIC + A | |
0.08 (0.01; 1.22) | 0.12 (0.01; 1.90) | 0.14 (0.00; 4.16) | 0.14 (0.00; 16.88) | 0.24 (0.09; 0.65) | 0.25 (0.06; 1.00) | 0.25 (0.07; 0.87) | 0.50 (0.19; 1.30) | 1.05 (0.04; 30.26) | TACE |
- Citation: Zhou SA, Zhou QM, Wu L, Chen ZH, Wu F, Chen ZR, Xu LQ, Gan BL, Jin HS, Shi N. Efficacy of hepatic arterial infusion chemotherapy and its combination strategies for advanced hepatocellular carcinoma: A network meta-analysis. World J Gastrointest Oncol 2024; 16(8): 3672-3686
- URL: https://www.wjgnet.com/1948-5204/full/v16/i8/3672.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v16.i8.3672