Curcumin for gastric cancer: Mechanism prediction via network pharmacology, docking, and in vitro experiments

doi:10.4251/wjgo.v16.i8.3635

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 16, Issue 8

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (18)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-10) series, Tables (1-5) series.

Item

Count

PDF

HTML

Figures (1-10)

Tables (1-5)

Sum=25

Aug 15, 2024 (publication date) through Aug 7, 2024

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Oncology

ISSN

1948-5204

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Basic Study

World J Gastrointest Oncol. Aug 15, 2024; 16(8): 3635-3650
Published online Aug 15, 2024. doi: 10.4251/wjgo.v16.i8.3635

Table 5 Binding information for curcumin and docking of the hub target molecules

Hub targets	Binding energy (kcal/mol)	Hydrogen bonds				Hydrogen bonds, lengths
ESR1	-6.3	Ala307 (A)	Gly366 (A)		Ser305 (A)	2.82Å	3.06Å	2.95Å	3.47Å
EGFR	-7.8	Lys745 (A)				3.31Å
CYP3A4	-8.4	-				-
MAPK14	-7.9	Lys53 (A)				3.22Å
CYP1A2	-9.5	Arg108 (A)		Arg456 (A)		3.15Å		3.15Å
CYP2B6	-9.3	Arg98 (A)				2.95Å		2.96Å

ESR1: Estrogen receptor 1; EGFR: Epidermal growth factor receptor; CYP3A4: Cytochrome P450 family 3 subfamily A member 4; MAPK14: Mitogen-activated protein kinase 14; CYP1A2: Cytochrome P450 family 1 subfamily A member 2; CYP2B6: Cytochrome P450 family 2 subfamily B member 6.

Citation: Yang PH, Wei YN, Xiao BJ, Li SY, Li XL, Yang LJ, Pan HF, Chen GX. Curcumin for gastric cancer: Mechanism prediction via network pharmacology, docking, and in vitro experiments. World J Gastrointest Oncol 2024; 16(8): 3635-3650
URL: https://www.wjgnet.com/1948-5204/full/v16/i8/3635.htm
DOI: https://dx.doi.org/10.4251/wjgo.v16.i8.3635