Curcumin for gastric cancer: Mechanism prediction via network pharmacology, docking, and in vitro experiments

Table 4 Top 10 representative pathways according to gene count

Pathway ID	Pathway	Corrected P value	Gene count	Annotated genes
KEGG: hsa04068	FoxO signaling pathway	7.66E-07	8	MAPK10, MAPK8, PLK1, CDK2, EP300, MAPK14, EGFR, TGFBR1
KEGG: hsa05200	Pathways in cancer	1.19E-04	9	MAPK10, MAPK8, RXRA, GSTP1, CDK2, EP300, PPARG, EGFR, TGFBR1
KEGG: hsa00982	Drug metabolism - cytochrome P450	1.50E-04	5	CYP2B6, CYP2D6, GSTP1, CYP1A2, CYP3A4
KEGG: hsa00980	Metabolism of xenobiotics by cytochrome P450	2.08E-04	5	CYP2B6, CYP2D6, GSTP1, CYP1A2, CYP3A4
KEGG: hsa05120	Epithelial cell signaling in Helicobacter pylori infection	0.002430862	4	MAPK10, MAPK8, MAPK14, EGFR
KEGG: hsa04912	GnRH signaling pathway	0.00577562	4	MAPK10, MAPK8, MAPK14, EGFR
KEGG: hsa04620	Toll-like receptor signaling pathway	0.008806272	4	MAPK10, MAPK8, TLR9, MAPK14
KEGG: hsa04071	Sphingolipid signaling pathway	0.012342719	4	MAPK10, MAPK8, MAPK14, CTSD
KEGG: hsa05169	Epstein-Barr virus infection	0.012905562	4	MAPK10, MAPK8, CDK2, MAPK14
KEGG: hsa04110	Cell cycle	0.013483025	4	PLK1, CHEK1, CDK2, EP300

ESR1: Estrogen receptor 1; EGFR: Epidermal growth factor receptor; CYP3A4: Cytochrome P450 family 3 subfamily A member 4; MAPK14: Mitogen-activated protein kinase 14; CYP1A2: Cytochrome P450 family 1 subfamily A member 2; CYP2B6: Cytochrome P450 family 2 subfamily B member 6.