Targeting colorectal cancer with Herba Patriniae and Coix seed: Network pharmacology, molecular docking, and in vitro validation

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Aug 15, 2024 (publication date) through Nov 12, 2024

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical and Translational Research

World J Gastrointest Oncol. Aug 15, 2024; 16(8): 3539-3558
Published online Aug 15, 2024. doi: 10.4251/wjgo.v16.i8.3539

Table 4 Top five Kyoto Encyclopedia of Genes and Genomes pathways in the herbal ingredient-target-pathway-disease network

KEGG pathway name	Degree	CC	BC
Pathways in cancer	70	0.457	0.163
PI3K-Akt signaling pathway	47	0.404	0.052
Proteoglycans in cancer	34	0.393	0.030
Chemical carcinogenesis-receptor activation	33	0.391	0.038
MicroRNAs in cancer	32	0.388	0.035

CC: Closeness centrality; BC: Betweenness centrality; KEGG: Kyoto Encyclopedia of Genes and Genomes; PI3K: Phosphoinositide 3-kinase.

Citation: Wang CL, Yang BW, Wang XY, Chen X, Li WD, Zhai HY, Wu Y, Cui MY, Wu JH, Meng QH, Zhang N. Targeting colorectal cancer with Herba Patriniae and Coix seed: Network pharmacology, molecular docking, and in vitro validation. World J Gastrointest Oncol 2024; 16(8): 3539-3558
URL: https://www.wjgnet.com/1948-5204/full/v16/i8/3539.htm
DOI: https://dx.doi.org/10.4251/wjgo.v16.i8.3539