Targeting colorectal cancer with Herba Patriniae and Coix seed: Network pharmacology, molecular docking, and in vitro validation

doi:10.4251/wjgo.v16.i8.3539

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical and Translational Research

World J Gastrointest Oncol. Aug 15, 2024; 16(8): 3539-3558
Published online Aug 15, 2024. doi: 10.4251/wjgo.v16.i8.3539

Table 3 Top five active ingredients in the herbal ingredient-target-pathway-disease network

Molecule name	Degree	CC	BC
Acacetin	56	0.433	0.107
Luteolin	54	0.430	0.089
Quercetin	53	0.428	0.090
Bolusanthol B	49	0.419	0.148
Sinoacutine	45	0.414	0.127

CC: Closeness centrality; BC: Betweenness centrality.

Citation: Wang CL, Yang BW, Wang XY, Chen X, Li WD, Zhai HY, Wu Y, Cui MY, Wu JH, Meng QH, Zhang N. Targeting colorectal cancer with Herba Patriniae and Coix seed: Network pharmacology, molecular docking, and in vitro validation. World J Gastrointest Oncol 2024; 16(8): 3539-3558
URL: https://www.wjgnet.com/1948-5204/full/v16/i8/3539.htm
DOI: https://dx.doi.org/10.4251/wjgo.v16.i8.3539