Effect of perioperative chemotherapy on resection of isolated pulmonary metastases from colorectal cancer: A single center experience

Table 5 Multivariate analysis of recurrence and survival

		HR	95%CI	P value
Recurrence
Age at time of pulmonary surgery	≤ 60 years
	> 60 years	0.59	0.32-1.10	0.099
Number of metastatic lesions	1
	≥ 2	2.22	1.12-4.38	0.022
Primary tumor N stage	N0
	N1 or N2	1.51	0.79-2.87	0.215
DFI	≤ 600
	> 600	0.78	0.42-1.45	0.432
Survival
Age at time of pulmonary surgery	≤ 60 years
	> 60 years	1.57	0.69-3.58	0.286
Primary tumor T stage	T1 or T2
	T3 or T4	1.16	0.38-3.57	0.079
Primary tumor N stage	N0
	N1 or N2	1.35	0.58-3.13	0.485
Pulmonary metastasis	Synchronous
	Metachronous	2.35	0.29-18.85	0.423
Perioperative chemotherapy	No
	Yes	0.48	0.21-1.09	0.079
Number of metastatic lesions	1
	≥ 2	2.51	1.02-6.15	0.045
Type of resection	Lobectomy
	Sublobar resection	0.42	0.19-0.94	0.035
DFI	≤ 600
	> 600	0.35	0.15-0.82	0.016

Bold values indicate P values below the statistical significance threshold. DFI: Disease-free interval; HR: hazard ratio; 95%CI: 95% confidence interval.