RBM5 suppresses proliferation, metastasis and glycolysis of colorectal cancer cells via stabilizing phosphatase and tensin homolog mRNA

Figure 6 Overexpression of RNA binding motif 5 inhibits the tumor formation and metastasis of colorectal cancer in vivo. A: Images of a tumor in xenograft mice, n = 5; B: The tumor volume in every 7 days; the construction of tumor growth curves of mice, n = 5; C: Xenograft mice’ average tumor weight, n = 5; D: Protein expression levels of RNA binding motif 5, phosphatase and tensin homolog (PTEN) and Ki67 in xenograft mice’ tumor tissues were detected by immunohistochemical staining, n = 5; E: Protein levels of PTEN, phosphoinositide 3-kinase, phosphorylated-protein kinase B, and AKT were determined by Western blot; F: Tumor liver metastasis was assessed by haematoxylin and eosin staining, n = 5. ^aP < 0.05,^bP < 0.01,^cP < 0.001. RBM5: RNA binding motif 5; PTEN: Phosphatase and tensin homolog; PI3K: Phosphoinositide 3-kinase; p-AKT: Phosphorylated-protein kinase B.