Aldehyde dehydrogenase 2 family member repression promotes colorectal cancer progression by JNK/p38 MAPK pathways-mediated apoptosis and DNA damage

Figure 6 Aldehyde dehydrogenase 2 family member-deficiency leads to accumulated acetaldehyde and increased DNA damage in vivo. A: The tumor growth in xenograft tumor mice model; B: The tumor volumes in shRNA aldehyde dehydrogenase 2 family member-SK-CO-1 mouse xenograft models treatment of imatinib; C: The mice were killed, and the tumor weight was assessed; D: Relative quantification of acetaldehyde of mice tumor tissues; E: Detection of Bax, Bcl-2, γH2AX, p-JNK/JNK, and p-P38 MAPK/P38 MAPK protein levels in tumor tissue by western blot. Results are the mean ± SD of triplicate samples. t-test, ^cP < 0.001.