Aldehyde dehydrogenase 2 family member repression promotes colorectal cancer progression by JNK/p38 MAPK pathways-mediated apoptosis and DNA damage

Figure 4 represses MAPK activation to inhibit cell apoptosis of colorectal cancer cells. A: Phosphorylation of JNK and P38 MAPK in CL-40 and SK-CO-1 cells was measured by western blot; B: Flow cytometric analysis of apoptosis of CL-40 and SK-CO-1 cells; C: Detection of apoptosis marker protein (Bax and Bcl-2) in shRNA aldehyde dehydrogenase 2 family member-cells co-treated with Alda-1, SP600125, or SB203580. Data are displayed as the mean ± SD. ^aP < 0.05, ^bP < 0.01,^cP < 0.001. ALDH2: Aldehyde dehydrogenase 2 family member.