Weiwei Decoction alleviates gastric intestinal metaplasia through the olfactomedin 4/nucleotide-binding oligomerization domain 1/caudal-type homeobox gene 2 signaling pathway

Figure 7 Weiwei Decoction inhibits cytokines and chemokines in gastric intestinal metaplasia. A: Enzyme-linked immunosorbent assay was utilized to detect interferon-gamma, interleukin (IL)-6, IL-17, macrophage chemoattractant protein-1, and macrophage inflammatory protein 1 alpha in intestinal metaplasia rats serum (n = 6); B: Relative mRNA expression of tumor necrosis factor alpha, IL-6, and IL-8 in GES-1 cells (n = 3). ^aP < 0.05, ^bP < 0.01, ^cP < 0.001 vs control group; ^dP < 0.05, ^eP < 0.01, ^fP < 0.001 vs model group; ^gP < 0.05, ^hP < 0.01, ⁱP < 0.001 vs folic acid group. IL: Interleukin; MIP: Macrophage inflammatory protein; MCP: Macrophage chemoattractant protein; IFN: Interferon; WWD: Weiwei Decoction; FA: Folic acid; TNF: Tumor necrosis factor.