Weiwei Decoction alleviates gastric intestinal metaplasia through the olfactomedin 4/nucleotide-binding oligomerization domain 1/caudal-type homeobox gene 2 signaling pathway

Figure 1 The olfactomedin 4/nucleotide-binding oligomerization domain 1/caudal-type homeobox gene 2 pathway is a characteristic of gastric intestinal metaplasia tissues. A: The representative images of Immunohistochemistry (IHC) staining for olfactomedin 4 (OLFM4), nucleotide-binding oligomerization domain 1 (NOD1), and caudal-type homeobox gene 2 (CDX2) in normal and intestinal metaplasia (IM) tissues; B: OLFM4, NOD1, and CDX2 immunoreactivity scores in normal and IM tissues were compared; C: Correlation of OLFM4 with CDX2, NOD1 with CDX2, and OLFM4 with NOD1 in gastric tissues by Spearman’s correlation analysis. ^aP < 0.01, ^bP < 0.001 vs control group. OLFM4: Olfactomedin 4; NOD1: Nucleotide-binding oligomerization domain 1; CDX2: Caudal-type homeobox gene 2; IM: Intestinal metaplasia.