Multi-Omics analysis elucidates tumor microenvironment and intratumor microbes of angiogenesis subtypes in colon cancer

Figure 6 Identification of differentially expressed genes between angiogenesis subtypes and construction of the prognostic model. A: Differentially expressed genes (DEGs) between two angiogenesis subtypes; B and C: Kyoto Encyclopedia of Genes and Genomes and Gene Ontology enrichment analyses of DEGs between two angiogenesis subtypes; D: Univariate Cox regression analysis of each DEG between two angiogenesis subtypes and 13 genes with P < 0.05; E: Cross-validation for tuning the parameter selection in the Least absolute shrinkage and selection operator regression; F: Sankey diagram of subtype distributions in angiogenesis subtypes and angiogenesis-related score (ARS) groups; G: Differences in ARS among two angiogenesis subtypes in colon cancer patients (P < 0.001); H: Heatmap (green: low expression level; brown: high expression level) of the angiogenesis-related genes between the low and high ARS groups; I: Correlations between the expression of 36 Angiogenesis related-genes and selected 6 genes in the ARS model. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001.