Yiqi Jiedu Huayu decoction inhibits precancerous lesions of chronic atrophic gastritis by inhibiting NLRP3 inflammasome-mediated pyroptosis

Figure 3 Yiqi Jiedu Huayu inhibited NLRP3 inflammasome-mediated pyroptosis in chronic atrophic gastritis rats with precancerous lesion of gastric cancer. We performed an orally taken of N-methyl-N’-nitro-N-nitrosoguanidine and Helicobacter pylori in rats to induce chronic atrophic gastritis with precancerous lesion combined with Yiqi Jiedu Huayu decoction treatment. A and B: Serum interleukin (IL)-18 and IL-1β levels were detected using enzyme-linked immunosorbent assay; C: Immunohistochemistry was performed to assess NLRP3 level in gastric mucosa; D-F: NLRP3, IL-18 and IL-1β mRNA levels in gastric mucosa were measured using quantitative real-time polymerase chain reaction. The measurement data were presented as mean ± SD. n = 10. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. YJHD: Yiqi Jiedu Huayu decoction; IL: Interleukin.