Yiqi Jiedu Huayu decoction inhibits precancerous lesions of chronic atrophic gastritis by inhibiting NLRP3 inflammasome-mediated pyroptosis

Figure 1 Yiqi Jiedu Huayu attenuated pathological changes in gastric mucosa of chronic atrophic gastritis rats with precancerous lesion of gastric cancer. The chronic atrophic gastritis mouse model with precancerous lesion was established by oral administration of N-methyl-N’-nitro-N-nitrosoguanidine and Helicobacter pylori, and they were further treated with Yiqi Jiedu Huayu. A and B: Body weight and daily food intake of rats were presented; C: Hematoxylin-eosin staining was employed to examine pathological changes in gastric mucosa. Black arrows indicated disruption of the various components of the gastric wall structure, green arrows denoted atrophied gastric glands, and yellow arrows pointed to infiltrating inflammatory cells; D: Alcian blue-Periodic acid Schiff staining was performed to analyze gastric intestinal metaplasia; E: Ki67 level in gastric mucosa was assessed using IHC. The measurement data were presented as mean ± SD. n = 10. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. YJHD: Yiqi Jiedu Huayu decoction; HE: Hematoxylin-eosin.