Integrated single-cell and bulk RNA sequencing revealed an epigenetic signature predicts prognosis and tumor microenvironment colorectal cancer heterogeneity

Figure 4 Clinical association of the signature. A: The signature is statistically correlated with TNM stage, but not age and gender; B: Cox multivariate regression of the signature and clinical indicators suggests that the signature is an independent indicator for survival; C: The signature is positively associated with both PD-1 and PD-L1 gene expression; D: Nomogram for five-year survival; E: Calibrate curve revealed the signature is a valuable marker for predicting survival of colorectal cancer. ^aP < 0.05; ^cP < 0.001.