Comprehensive serum proteomics profiles and potential protein biomarkers for the early detection of advanced adenoma and colorectal cancer

Figure 6 Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes enrichment analysis of differentially expressed proteins between the advanced adenoma group and colorectal cancer group. A: Gene Ontology enrichment analysis: Differentially expressed proteins (DEPs) are mainly enriched in amide biosynthetic process, protein binding, and extracellular exosome; B: Kyoto Encyclopedia of Genes and Genomes enrichment analysis: DEPs are mainly enriched in metabolic pathways, ribosomes, and PPAR signaling pathway. AA: Advanced adenoma; CRC: Colorectal cancer; DEPs: Differentially expressed proteins; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes.