Comprehensive serum proteomics profiles and potential protein biomarkers for the early detection of advanced adenoma and colorectal cancer

Figure 5 Partial least squares discrimination analysis plot, volcano plot, and heatmap between the advanced adenoma group and colorectal cancer group. A: Partial least squares discrimination analysis shows the protein expression in the advanced adenoma group (green) and colorectal cancer group (orange); B: Volcano plot shows the fold change of the identified proteins between the two groups; C: Hierarchical clustering analysis shows the upregulated (red) and downregulated (green) differentially expressed proteins between the two groups. AA: Advanced adenoma; CRC: Colorectal cancer; PLS-DA: Partial least squares discrimination analysis.