Comprehensive serum proteomics profiles and potential protein biomarkers for the early detection of advanced adenoma and colorectal cancer

Figure 4 Gene Ontology enrichment and Kyoto Encyclopedia of Genes and Genomes enrichment analysis of differentially expressed proteins between the normal control group and colorectal cancer group. A: Gene Ontology enrichment analysis: Differentially expressed proteins (DEPs) are mainly enriched in amide biosynthetic process, protein binding, and secretory granule lumen; B: Kyoto Encyclopedia of Genes and Genomes enrichment analysis: DEPs are mainly enriched in metabolic pathways, ribosomes, and endocytosis. NC: Normal control; CRC: Colorectal cancer; DEPs: Differentially expressed proteins; GO: Gene Ontology; KEGG: Kyoto Encyclopedia of Genes and Genomes.