Comprehensive serum proteomics profiles and potential protein biomarkers for the early detection of advanced adenoma and colorectal cancer

Figure 1 Partial least squares discrimination analysis plot, volcano plot, and heatmap between the normal control group and advanced adenoma group. A: Partial least squares discrimination analysis shows the protein expression in the normal control group (blue) and advanced adenoma group (green); B: Volcano plot shows the fold change of the identified proteins between the two groups; C: Hierarchical clustering analysis shows the upregulated (red) and downregulated (green) differentially expressed proteins between the two groups. NC: Normal control; AA: Advanced adenoma; PLS-DA: Partial least squares discrimination analysis.