Adipocytes impact on gastric cancer progression: Prognostic insights and molecular features

Table 4 Univariate and multivariate analysis of prognostic factors for overall survival in the validation set

Parameter	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age in yr		0.003
≤ 60	0.518 (0.354-0.757)	0.004	0.576 (0.392-0.846)	0.018
> 60
Sex		0.219
Male
Female	0.752 (0.509-1.111)	0.230
Adipose infiltration		< 0.001
High
Low	0.256 (0.180-0.364)	< 0.001	0.283 (0.198-0.404)	< 0.001
Perineural invasion		0.401
No
Yes	1.225 (0.823-1.823)	0.401
Vascular invasion		0.045
No
Yes	1.570 (1.097-2.249)	0.039	1.401 (0.963-2.038)	0.139
M stage		0.001
M0
M1	3.780 (2.124-6.728)	< 0.001	2.355 (1.278-4.338)	0.021
T stage		0.859
T1
T2	0.930 (0.614-1.411)	0.775
T3	0.839 (0.522-1.348)	0.542
T4	1.382 (0.522-3.661)	0.585
N stage		0.845
N0
N1	0.829 (0.447-1.536)	0.616
N2	1.172 (0.711-1.933)	0.601
N3	1.478 (0.910-2.402)	0.185

CI: Confidence interval; HR: Hazard ratio.