Effectiveness and safety of sequential transarterial chemoembolization and microwave ablation for subphrenic hepatocellular carcinoma: A comprehensive evaluation

Table 3 Univariate and multivariate analysis of local tumor progression using Cox regression model

Variable	Local tumor pregression
	Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Female sex	0 (0-Inf)	0.086	ND	ND
Age	1.02 (0.96-1.09)	0.487	ND	ND
Etiology		0.407	ND	ND
HCV	Reference		ND	ND
HBV	1.31 (0.17-10.11)		ND	ND
Non-viral	0 (0-Inf)		ND	ND
CP B	0.66 (0.08-5.08)	0.668	ND	ND
AFP ≥ 200 ng/mL	2.07 (0.45-9.46)	0.388	ND	ND
PLT	1.0031 (0.9966-1.0096)	0.381	ND	ND
Non-undergone hepatectomy	0.46 (0.10-2.08)	0.271	ND	ND
Amount of iodized oil in mL	1.34 (1.15-1.57)	0.001	1.52 (1.11-2.08)	0.009
Amount of epirubicin in mg	1.07 (0.96-1.19)	0.174	ND	ND
Tumor number of 2	3.23 (0.70-14.80)	0.186	13.22 (1.62-107.51)	0.016
Tumor size in cm	2.59 (1.48-4.52)	< 0.001	ND	ND
Transpulmanory: 1 vs 0	1.50 (0.48-4.72)	0.487	ND	ND
Nonsubphrenic vs subphrenic	1.29 (0.42-4.00)	0.661	ND	ND

AFP: Alpha-fetoprotein; CI: Confidence interval; CP: Child-Pugh classification; HBV: Hepatic B virus; HCV: Hepatic C virus; HR: Hazard ratio; ND: Not done; PLT: Platelet.