Role of molecular biology in the management of pancreatic cancer

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Jul 15, 2024 (publication date) through Jan 5, 2025

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jul 15, 2024; 16(7): 2902-2914
Published online Jul 15, 2024. doi: 10.4251/wjgo.v16.i7.2902

Table 2 Safety and toxicity data regarding KRASG12C inhibitors in pancreatic ductal adenocarcinoma

	Adagrasib (n = 21)[57]	Sotorasib (n = 38)[63]
Objective response rate (95%CI)	33 (15-57)	21 (10-37)
Disease control rate	81	84
Median duration of response (months)	NA	5.7 (1.6-non evaluable)
Progression-free survival (months) (95%CI)	5.4 (3.9-8.2)	4.0 (2.8-5.6)
Overall survival (months) (95%CI)	8.0 (5.2-11.8)	6.9 (5.0-9.1)
Grade 3-4 toxicities	27	16
Dose reduction	40 (solid tumours)	13
Discontinuation for toxicity	0	0

Citation: Boileve A, Smolenschi C, Lambert A, Boige V, Tarabay A, Valery M, Fuerea A, Pudlarz T, Conroy T, Hollebecque A, Ducreux M. Role of molecular biology in the management of pancreatic cancer. World J Gastrointest Oncol 2024; 16(7): 2902-2914
URL: https://www.wjgnet.com/1948-5204/full/v16/i7/2902.htm
DOI: https://dx.doi.org/10.4251/wjgo.v16.i7.2902