Role of molecular biology in the management of pancreatic cancer

doi:10.4251/wjgo.v16.i7.2902

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World Journal of Gastrointestinal Oncology

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World J Gastrointest Oncol. Jul 15, 2024; 16(7): 2902-2914
Published online Jul 15, 2024. doi: 10.4251/wjgo.v16.i7.2902

Table 1 Main actionable molecular alterations in pancreatic ductal adenocarcinoma and their current European Society for Medical Oncology scale for clinical actionability of molecular target classification

Biomarker	Targeted therapy	ESCAT classification	Ref.
BRCA1, BRCA2 germinal	Olaparib	IA	[87]
BRCA1, BRCA2 germinal/somatic	Rucaparib	IB	[86,88]
PALB2 germinal/somatic	Rucaparib	IB	[88]
NTRK fusions	Larotrectinib, entrectinib	IC	[27,89]
MSI high	Pembrolizumab	IC	[25]
RET fusions	Pralseltinib, selpercatinib	IC	[90,91]
NRG1 fusions	Zenocutuzumab	IIB	[30]
KRAS^G12C	Sotorasib, adagrasib	IIB	[55,56]
FGFR2 Fusions	Pemigatinib, infigratinib, futibatinib	IIIA	[92,93]
PIK3CA mutations	Alpelisib, buparlisib	IIIA	[94,95]
BRAF^V600Emutation	Dabrafenib + trametinib, Binimetinib + encorafenib	IIIA	[96,97]
ALK/ROS1 fusions	Crizotinib, ceritinib, alectinib	IIIA	[98-100]
ERBB2 amplification	Trastuzumab + pertuzumab, T-DM1	IIIA	[101,102]

ESCAT: European Society for Medical Oncology Scale for Clinical Actionability of molecular Targets; MSI: Microsatellite instability.

Citation: Boileve A, Smolenschi C, Lambert A, Boige V, Tarabay A, Valery M, Fuerea A, Pudlarz T, Conroy T, Hollebecque A, Ducreux M. Role of molecular biology in the management of pancreatic cancer. World J Gastrointest Oncol 2024; 16(7): 2902-2914
URL: https://www.wjgnet.com/1948-5204/full/v16/i7/2902.htm
DOI: https://dx.doi.org/10.4251/wjgo.v16.i7.2902