Aspirin suppresses hepatocellular carcinoma progression by inhibiting platelet activity

Figure 3 Platelets promote the formation of an inflammatory microenvironment in hepatocellular carcinoma. A and B: Real time polymerase chain reaction (RT-PCR) was used to detect the effects of platelet plasma and platelet-rich plasma on the expression of inflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α, and iNOS) and chemokines (CCL2, CCL5) in hepatocellular carcinoma (HCC) cells; C and D: RT-PCR was used to detect the effect of platelets (PLTs) on the expression of inflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α, and iNOS) and chemokines (CCL2 and CCL5) in HCC cells. The figure shows the mean ± SD of the experimental results, with asterisks denoting significant differences between the two groups (^aP < 0.05, ^bP < 0.01, ^cP < 0.001). PPP: Platelet plasma; PRP: Platelet-rich plasma; FBS: Fetal bovine serum; PLT: Platelets.