Shi-pi-xiao-ji formula suppresses hepatocellular carcinoma by reducing cellular stiffness through upregulation of acetyl-coA acetyltransferase 1

Figure 5 Representative atomic force microscope images and Young’s modulus values. A and B: Representative atomic force microscope (AFM) images (A) and Young’s modulus values (B) of MHCC97H cells in the vehicle, Shi-pi-xiao-ji (SPXJ)-serum, methyl-β-cyclodextrin (MβCD), and water-soluble cholesterol (Chol) groups; C and D: Representative AFM images (C) and Young’s modulus values (D) of HepG2 cells in the vehicle, SPXJ-serum, MβCD, and Chol groups. The results are expressed as means ± SEM (n= 3). ^aP < 0.05, ^bP < 0.01, ^cP < 0.001. SPXJ: Shi-pi-xiao-ji; MβCD: Methyl-β-cyclodextrin; Chol: Water-soluble cholesterol.