Bidirectional effects of the tryptophan metabolite indole-3-acetaldehyde on colorectal cancer

Figure 6 Target protein function prediction and core protein mining of indole-3-acetaldehyde. A: Analysis based on Gene Ontology database; B: Analysis based on Kyoto Encyclopedia of Genes and Genome database; C and D: Results of the cytoHubba plug-in analysis; E and F: Results of the MCODE plug-in analysis. ACE: Angiotensin converting enzyme; CTSB: Cathepsin B; MPO: Myeloperoxidase; MMP: Matrix Metallopeptidase; CTSS: Cathepsin S; PARP: Poly (ADP-Ribose) Polymerase; HDAC: Histone deacetylase; CSF1R: Colony stimulating factor 1 receptor; TYR: Tyrosinase; CDK: Cyclin dependent kinase; MAPK: Mitogen-activated protein kinase; HMOX: Heme oxygenase 1; TNFRSF1A: TNF receptor superfamily member 1A; NCOR: Nuclear receptor corepressor; GSK3B: Glycogen synthase kinase 3 beta; AKT: AKT serine/threonine kinase; NR3C1: Nuclear receptor subfamily 3 group c member 1; DRD2: Dopamine receptor D2; MAOA: Monoamine oxidase A; MAOB: Monoamine oxidase B; SLC6A3: Solute carrier family 6 member 3.