Complement factor I knockdown inhibits colon cancer development by affecting Wnt/β-catenin/c-Myc signaling pathway and glycolysis

Figure 6 Knockdown of complement factor I inhibited tumor growth in colon cancer model mice. A: Representative images of colon cancer (CC) xenograft tumors in the Lv-sh-NC and Lv-sh-complement factor I (CFI) groups; B: Tumor growth curves and weight determinations; C: The histological alterations in CC tumors were observed using hematoxylin and eosin staining; D: Immunohistochemistry was employed to measure Ki67 levels in the Lv-sh-NC and Lv-sh-CFI groups. ^cP < 0.001 vs Lv-sh-NC group (n = 6 mice per group). CFI: Complement factor I.