Early monitoring values of oncogenic signalling molecules for hepatocellular carcinoma

Figure 4 Abnormal activation of Wnt3a in hepatocarcinogenesis[49,53,56,57,61]. The Wnt/β-catenin signalling pathway contains 19 mammalian Wnt proteins. Wnt3a gene located on chromosome 17q21 is regarded as an activator of the canonical Wnt pathway, which induces β-catenin accumulation. An increase in Wnt3a is closely related to hepatocyte malignant transformation and could be a marker for monitoring hepatocarcinogenesis. FA: Fatty acid; PPARα: Peroxisome proliferation activated receptor α.