Dynamic contrast enhanced ultrasound in differential diagnosis of hepatocellular carcinoma: A systematic review and meta-analysis

Table 4 Dynamic continuous variables of hepatocellular carcinoma vs intracellular cholangiocarcinoma lesions in the included publications

	Ainora et al[5], 2023		Dong et al[15], 2023
	HCC (n = 38)	ICC (n = 44)	HCC (n = 24)	ICC (n = 30)
Rise time lesion (s)	10.9 ± 3.8	8.1 ± 4.1	11.9 ± 5.3	7.5 ± 3.0
Fall time lesion (s)	37.5 ± 19.5	35.4 ± 23.9	27.7 ± 10.8	14.9 ± 5.9
mTTL lesion (s)	67.0 ± 52.0	42.9 ± 46.1	68.9 ± 32.4	42.2 ± 18.0
TTP lesion (s)	12.5 ± 4.3	9.1 ± 5.8	17.6 ± 9.6	12.8 ± 6.4
PE percent change	0.66 ± 1.35	-0.04 ± 1.38	1.28 ± 0.47	1.16 ± 0.90
WiR percent change	2.41 ± 3.96	1.32 ± 1.91	2.33 ± 1.19	2.38 ± 2.33
WiAUC percent change	-0.22 ± 0.72	-0.52 ± 0.36	0.79 ± 0.45	0.61 ± 0.51
WoAUC percent change	-0.11 ± 0.74	-0.41 ± 0.53	0.85 ± 0.53	0.53 ± 0.42
WiWoAUC percent change	-0.13 ± 0.70	-0.39 ± 0.39	0.83 ± 0.50	0.55 ± 0.44

HCC: Hepatocellular carcinoma; ICC: Intracellular cholangiocarcinoma; mTTL: Mean transit time local; TTP: Time to peak; PE: Peak enhancement; WiR: Wash-in rate; WiAUC: Wash-in area under the curve; WiWoAUC: Wash-in and wash-out area under the curve; WoAUC: Wash-out area under the curve.