Circ_0004592: An auxiliary diagnostic biomarker for gastric cancer

Table 3 The correlation between circ_0004592 expression and clinicopathological parameters of gastric cancer patients

Characteristics	No. of patients	Low expression	High expression	P value
Gender
Male	61	33	28	0.206
Female	39	17	22
Age
≤ 60	34	14	20	0.146
> 60	66	36	30
Tumor size, cm
< 5	72	36	36	0.176
≥ 5	28	14	14
Pathological differentiation
Poor-undifferentiation	59	22	37	0.002b
Well-moderate	41	28	13
Tumor depth
T1-T2	50	32	18	0.004b
T3-T4	50	18	32
Lymph node metastasis
Yes	49	19	30	0.022a
No	51	31	20
Nerve/vascular invasion
Positive	48	22	26	0.274
Negative	52	28	24
CEA
Positive	60	36	24	0.012a
Negative	40	14	26
CA199
Positive	51	25	26	0.500
Negative	49	25	24

^aP <0.05.

^bP < 0.01.

Statistical analyses were carried out using Pearson χ² test or Fisher’s exact test. were considered significant. CEA: Carcinoembryonic antigen; CA199: Cancer antigen 199; GC: Gastric cancer.