Bidirectional effects of the tryptophan metabolite indole-3-acetaldehyde on colorectal cancer

doi:10.4251/wjgo.v16.i6.2697

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jun 15, 2024; 16(6): 2697-2715
Published online Jun 15, 2024. doi: 10.4251/wjgo.v16.i6.2697

Table 2 Dock details of target proteins and indole-3-acetaldehyde

Term	Binding energy (kcal/mol)	Mode of action	Target point (s)
6ESM-IAAD	-6.21	H bond	Phe221
1UZE-IAAD	-6.49	H bond	Ala149, Val350
2RIQ-IAAD	-5.52	H bond	Phe304
7XJO-IAAD	-5.62	H bond	ILE21, Arg53
4C1M-IAAD	-5.41	H bond	Arg8

IAAD: Indole-3-acetaldehyde; Phe: Phenylalanine; Val: Valine; Ala: Alanine; Ile: Isoleucine; Arg: Arginine; 6ESM: Identity marker of matrix metalloproteinase-9 protein crystal structures in Protein Data Bank databases (https://www.rcsb.org/); 1UZE: Angiotensin converting enzyme; 2RIQ: Poly ADP-ribose polymerase-1; 7XJO: Matrix metalloproteinase-2; 4C1M: Myeloperoxidase.

Citation: Dai Z, Deng KL, Wang XM, Yang DX, Tang CL, Zhou YP. Bidirectional effects of the tryptophan metabolite indole-3-acetaldehyde on colorectal cancer. World J Gastrointest Oncol 2024; 16(6): 2697-2715
URL: https://www.wjgnet.com/1948-5204/full/v16/i6/2697.htm
DOI: https://dx.doi.org/10.4251/wjgo.v16.i6.2697