Socioeconomic traits and the risk of Barrett’s esophagus and gastroesophageal reflux disease: A Mendelian randomization study

Table 3 Univariate Mendelian randomization analysis for genetically causal associations of socioeconomic traits with Barrett’s esophagus risk

Exposure	Outcome	F statistic	SNP	IVW OR (95%CI)	P value	Weighted median OR (95%CI)	P value	MR-Egger OR (95%CI)	P value
Age completed full time education	BE	32.511	12	0.11 (0.05, 0.22)	7.830E-10	0.14 (0.05, 0.36)	7.010E-05	0.240 (0.02, 3.66)	0.328
Job involves heavy manual or physical work	BE	21.688	11	4.59 (2.15, 9.82)	8.370E-05	2.90 (1.18, 7.12)	0.020	0.480 (0.01, 47.14)	0.760
Average total household income before tax	BE	12.432	17	0.43 (0.23, 0.80)	0.007	0.51 (0.25, 1.03)	0.061	0.670 (0.05, 9.53)	0.771
Type of accommodation lived in: Apartment, duplex, or condominium	BE	17.781	0	NA	NA	NA	NA	NA	NA
Type of accommodation lived in: House or bungalow	BE	19.785	0	NA	NA	NA	NA	NA	NA
TDI at recruitment	BE	17.710	8	1.23 (0.51, 2.96)	0.648	0.92 (0.31, 2.71)	0.875	0.002 (0.00, 4.11)	0.162

BE: Barrett’s esophagus; 95%CI: 95% confidence interval; IVW: Inverse variance weighted; MR: Mendelian randomization; NA: Not available; OR: Odds ratio; SNPs: Single nucleotide polymorphisms; TDI: Townsend Deprivation Index.