Socioeconomic traits and the risk of Barrett’s esophagus and gastroesophageal reflux disease: A Mendelian randomization study

Table 2 Univariate Mendelian randomization analysis for genetically causal associations of socioeconomic traits with gastroesophageal reflux disease risk

Exposure	Outcome	F statistic	SNP	IVW OR (95%CI)	P value	Weighted median OR (95%CI)	P value	MR-Egger OR (95%CI)	P value
Age completed full time education	GERD	21.564	27	0.23 (0.18, 0.29)	3.120E-37	0.27 (0.21, 0.35)	3.890E-24	0.26 (0.08, 0.83)	0.032
Job involves heavy manual or physical work	GERD	15.312	10	2.62 (1.90, 3.63)	5.470E-09	2.35 (1.66, 3.34)	1.760E-06	0.37 (0.07, 1.83)	0.257
Average total household income before tax	GERD	16.722	9	0.45 (0.34, 0.59)	1.090E-08	0.55 (0.40, 0.76)	< 0.001	0.83 (0.07, 10.68)	0.891
Type of accommodation lived in: Apartment, duplex, or condominium	GERD	21.654	0	NA	NA	NA	NA	NA	NA
Type of accommodation lived in: House or bungalow	GERD	17.211	0	NA	NA	NA	NA	NA	NA
TDI at recruitment	GERD	22.719	6	2.77 (1.80, 4.28)	3.770E-06	2.32 (1.42, 3.79)	0.001	0.12 (0.01, 1.95)	0.211

95%CI: 95% confidence interval; GERD: Gastroesophageal reflux disease; IVW: Inverse variance weighted; MR: Mendelian randomization; NA: Not available; OR: Odds ratio; SNPs: Single nucleotide polymorphisms; TDI: Townsend Deprivation Index.