Socioeconomic traits and the risk of Barrett’s esophagus and gastroesophageal reflux disease: A Mendelian randomization study

Table 1 Genome-wide association study data sources and information included in the current study

Trait	Phenotype	Sample size	SNPs	Ancestry	Consortium	Link
Educational attainment	Age completed full time education	307897	9851867	European	MRC-IEU	https://gwas.mrcieu.ac.uk/datasets/ukb-b-6134/
Manual labor	Job involves heavy manual or physical work	263615	9851867	European	MRC-IEU	https://gwas.mrcieu.ac.uk/datasets/ukb-b-2002/
Household income	Average total household income before tax	397751	9851867	European	MRC-IEU	https://gwas.mrcieu.ac.uk/datasets/ukb-b-7408/
Residential environment	Type of accommodation lived in: Apartment, duplex, or condominium	360088	13586555	European	Neale Lab	https://gwas.mrcieu.ac.uk/datasets/ukb-d-670_2/
	Type of accommodation lived in: A house or bungalow	360088	13586555	European	Neale Lab	https://gwas.mrcieu.ac.uk/datasets/ukb-d-670_1/
Regional deprivation	Townsend Deprivation Index at recruitment	462464	9851867	European	MRC-IEU	https://gwas.mrcieu.ac.uk/datasets/ukb-b-10011/
Leisure or social activities	Leisure/social activities: Pub or social club	461369	9851867	European	MRC-IEU	https://gwas.mrcieu.ac.uk/datasets/ukb-b-4171/
	Leisure/social activities: Sports club or gym	461369	9851867	European	MRC-IEU	https://gwas.mrcieu.ac.uk/datasets/ukb-b-4000/
Esophageal diseases	Gastroesophageal reflux disease	602604	2320781	European	Ong JS	https://gwas.mrcieu.ac.uk/datasets/ebi-a-GCST90000514/
	Barrett’s esophagus	56429	2320520	European	Ong JS	https://gwas.mrcieu.ac.uk/datasets/ebi-a-GCST90000515/
Metabolic factors	Body mass index	322154	2554668	European	GIANT	https://gwas.mrcieu.ac.uk/datasets/ieu-a-835/
Psychological factors	Major depressive disorder	173005	13554550	European	PGC	https://gwas.mrcieu.ac.uk/datasets/ieu-a-1188/
Lifestyle factors	Cigarettes smoked per day	249752	12003613	European	GSCAN	https://gwas.mrcieu.ac.uk/datasets/ieu-b-142/
	Drinks per week	335394	11887865	European	GSCAN	https://gwas.mrcieu.ac.uk/datasets/ieu-b-73/
	Sleep duration	460099	9851867	European	MRC-IEU	https://gwas.mrcieu.ac.uk/datasets/ukb-b-4424/

GSCAN: Genome-wide association study and Sequencing Consortium of Alcohol and Nicotine Use; MRC-IEU: The Medical Research Council Integrative Epidemiology Unit; PGC: Psychiatric Genomics Consortium; SNPs: Single nucleotide polymorphisms.