Impact of baseline hepatitis B virus viral load on the long-term prognosis of advanced hepatocellular carcinoma treated with immunotherapy

Table 5 Univariate and multivariate analyses of the prognostic factors for overall survival

Factors	Univariate		Multivariate
	HR (95%CI)	P value	HR (95%CI)	P value
AFP (≤ 1210 vs > 1210)	0.57 (0.36-0.92)	0.020	0.95 (0.56-1.60)	0.849
Age (≥ 60 yr vs < 60 yr)	0.89 (0.57-1.39)	0.618	-	-
Alcohol (Yes vs No)	0.93 (0.59-1.46)	0.750	-	-
ALT (≤ 40 vs No)	1.29 (0.83-2.02)	0.256	-	-
Antiviral therapy (Yes vs No)	0.23 (0.12-0.44)	<0.001	0.43 (0.20-0.89)	0.024
BCLC stage (C vs B)	2.44 (1.48-4.05)	0.001	2.22 (1.27-3.86)	0.005
BMI (Normal vs Low)	0.61 (0.26-1.45)	0.265	-	-
BMI (Over obese vs Low)	2.86 (1.00-8.21)	0.051	-	-
BMI over (Weight vs Low)	0.83 (0.51-1.37)	0.469	-	-
Child Pugh score (B vs C)	1.01 (0.65-1.59)	0.952	-	-
Diabetes (Yes vs No)	0.97 (0.57-1.66)	0.922	-	-
Cirrhosis (Yes vs No)	1.16 (0.74-1.83)	0.515	-	-
ECOG (2 vs 0-1)	0.98 (0.63-1.53)	0.937	-	-
HBV (Positive vs Negative)	1.03 (0.63-1.66)	0.914	-	-
HBV-DNA (HBV ≤ 2000 vs HBV > 2000)	0.71 (0.45-1.12)	0.142	-	-
Hypertensive (Yes vs No)	1.07 (0.65-1.76)	0.781	-	-
PVTT (Yes vs No)	2.64 (1.61-4.31)	< 0.001	2.28 (1.29-4.05)	0.005
Post operative (Yes vs No)	1.18 (0.75-1.88)	0.472	-	-
Metastasis (Yes vs No)	0.65 (0.41-1.04)	0.071	-	-
Sex (male vs No)	1.00 (0.64-1.56)	0.994	-	-
Smoking (Yes vs No)	1.25 (0.77-2.04)	0.374	-	-
Total bilirubin (≤ 34 vs > 34)	0.86 (0.53-1.39)	0.533	-	-
Virus reactivation (Yes vs No)	1.29 (0.18-9.35)	0.803	-	-

HBV: Hepatitis B virus; BMI: Body mass index; ECOG: Eastern Cooperative Oncology Group; AFP: Alpha-fetoprotein; ALT: Alanine aminotransferase; BCLC: Barcelona Clinic Liver Cancer; PVTT: Portal vein tumor thrombosis.