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©The Author(s) 2024.
World J Gastrointest Oncol. Jun 15, 2024; 16(6): 2487-2503
Published online Jun 15, 2024. doi: 10.4251/wjgo.v16.i6.2487
Published online Jun 15, 2024. doi: 10.4251/wjgo.v16.i6.2487
Table 4 Multivariate analysis of factors associated with disease-free survival and overall survival
Features | DFS | OS | ||
HR | P value | HR | P value | |
Age | ||||
< 60 | Reference | - | Reference | - |
> 60 | 1.8 (1.2, 2.5) | 0.002 | 1.9 (1.3, 2.8) | < 0.001 |
Histological grade | ||||
Differentiated | Reference | Reference | ||
Undifferentiated | 1.7 (1.01, 2.7) | 0.043 | 2.0 (1.2, 3.3) | 0.007 |
WHO classification | ||||
1-2 | Reference | Reference | ||
3-4 | 2.5 (1.6, 3.8) | < 0.001 | 2.4 (1.5, 3.7) | < 0.001 |
Clinical stage | ||||
I-II | Reference | Reference | ||
III | 2.1 (1.4, 3-2) | < 0.001 | 1.9 (1.2, 2.9) | 0.004 |
IT CD3/HPF | ||||
High (> 58) | Reference | Reference | ||
Low (< 58) | 1.5 (1.02, 2.2) | 0.037 | 1.6 (1.1, 2.4) | 0.018 |
IT CD8/CD3 ratio | ||||
< 0.63 | Reference | Reference | ||
> 0.63 | 1.7 (1.2, 2.5) | 0.002 | 1.6 (1.1, 2.3) | 0.008 |
Non-significant variables | ||||
Sex | - | 0.939 | - | 0.51 |
Cardia-fundus | - | 0.398 | - | 0.212 |
Bormann | - | 0.328 | - | 0.315 |
Lauren | - | 0.311 | - | 0.291 |
Lymph nodes | - | 0.836 | - | 0.663 |
lymphovascular invasion | - | 0.972 | - | 0.277 |
H. pylori | - | 0.123 | - | 0.140 |
Deficient mismatch-repair | - | 0.973 | - | 0.365 |
HER2 | - | 0.222 | - | 0.114 |
IT TIL | - | 0.940 | - | 0.547 |
Stromal TIL | - | 0.818 | - | 0.806 |
IT CD8/HPF | - | 0.077 | - | 0.340 |
- Citation: Castaneda CA, Castillo M, Bernabe LA, Sanchez J, Fassan M, Tello K, Wistuba II, Chavez Passiuri I, Ruiz E, Sanchez J, Barreda F, Valdivia D, Bazan Y, Abad-Licham M, Mengoa C, Fuentes H, Montenegro P, Poquioma E, Alatrista R, Flores CJ, Taxa L. Association between Helicobacter pylori infection, mismatch repair, HER2 and tumor-infiltrating lymphocytes in gastric cancer. World J Gastrointest Oncol 2024; 16(6): 2487-2503
- URL: https://www.wjgnet.com/1948-5204/full/v16/i6/2487.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v16.i6.2487