Association between Helicobacter pylori infection, mismatch repair, HER2 and tumor-infiltrating lymphocytes in gastric cancer

Table 2 Relationship between level of infiltrating lymphocytes and clinicopathological features

Features	IT TILs	P value	ST TILs	P value	IB TILs	P value
Median	> 10%		> 30%		> 70%
Age		0.762		< 0.001		0.279
< 60	59.1		33.3		43
≥ 60	60.4		54.8		48.9
Sex		0.382		0.074		0.678
Female	57.7		39.8		45.1
Male	61.7		48.1		47.4
Gastric region location		0.450		0.049		0.160
No antrum	62		50		51.1
Antrum	58.4		40.5		43.3
Bormann		0.221		0.379		0.094
1	54.5		50		44.4
2	47.3		36.4		38.8
3	63.3		47.6		52.2
4	61		38.3		33.3
5	50		50		28.6
Lauren histology		0.891		< 0.001		0.002
Intestinal	58.7		58.74		53.1
Diffuse	58.9		20.4		28.6
Mixed	61.6		50		42.6
Grade		0.038		< 0.001		0.716
1	50		58.3		52.8
2	53.5		55.5		45.6
3	64.6		35.6		45.8
Lymphovascular invasion		0.028		0.520		0.968
No	51.9		41.7		46.2
Yes	62.9		44.9		46.5
Lymph node involvement		0.403		0.714		0.029
Yes	60.9		43.5		42.5
No	56.6		45.5		55.6
Pathology stage		0.016		0.001		0.001
I	42		28		41.5
II	65.4		55.8		60.4
III	60.3		41.5		38.9
Recurrence		0.230		0.003		0.369
No	61.9		49.5		48
Yes	56.3		35.2		42.7
H. pylori HE		0.009		0.445		0.411
Absent	65.9		47.6		47.5
Present	52.4		43.6		42.5
H. pylori qPCR		0.002		0.047		0.010
Absent	67.1		48.6		50.9
Present	43.7		34.1		29.9
CagA/H. pylori+		0.761		0.275		0.002
CagA-	40		46.7		64.3
CagA+	44.1		32.4		24.1
VacAs/H. pylori+		0.332		0.719		0.045
VacAs-	51.9		37		47.6
VacAs+	41.4		33.3		25
VacAs1/H. pylori+		0.530		0.887		0.894
VacAs1-	38.5		32.7		24.4
VacAs1+	44.7		34		25.7
VacAm/H. pylori+		0.824		0.535		0.265
VacAm-	41.9		38.7		38.5
VacAm+	44.2		32.6		26.8
VacAm1/H. pylori+		0.154		0.093		0.508
VacAm1-	55.2		44.8		21.7
VacAm1+	39.4		27.3		29.2
VacAs1+m1+/H. pylori+		0.937		0.953		0.527
No VacAs1+m1+	44.2		32.7		24.4
VacAs1+m1+	43.3		66.7		31.8
dMMR		0.875		0.019		0.010
No	58.7		38.9		38.6
Yes	59.6		51.5		54.2
HER2 positive		0.498		0.420		0.55
No	60.1		44.1		47.2
Yes	52.4		47.6		35.3

HE: Hematoxylin and eosin; IT: Intratumoral, ST: Stromal; TIL: Tumor-infiltrating lymphocytes; dMMR: Deficient mismatch-repair; H. pylori: Helicobacter pylori; HPF: High power field.