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©The Author(s) 2024.
World J Gastrointest Oncol. Jun 15, 2024; 16(6): 2487-2503
Published online Jun 15, 2024. doi: 10.4251/wjgo.v16.i6.2487
Published online Jun 15, 2024. doi: 10.4251/wjgo.v16.i6.2487
Table 1 Clinicopathological features and prognostic value
Feature | Total (n = 503) | % | Median | 5 yr DFS | P value | Median | 5 yr OS | P value |
Age, yr (19-95 yr) | ||||||||
< 60 | 231 | 45.9 | 4.6 | 49.1 | 0.043 | 7.0 | 52.5 | 0.009 |
≥ 60 | 272 | 54.1 | 3.0 | 39.6 | 3.7 | 41.6 | ||
Sex | ||||||||
Female | 252 | 50.1 | 3.3 | 43.7 | 0.582 | 3.8 | 45.3 | 0.319 |
Male | 251 | 49.9 | 4.0 | 44.6 | 4.5 | 48.2 | ||
Bormann | ||||||||
I-II | 90 | 18.1 | NA | 65.4 | < 0.001 | NA | 66.0 | 0.002 |
III | 311 | 62.7 | 2.9 | 40.6 | 4.0 | 44.4 | ||
IV-V | 95 | 19.2 | 2.6 | 36.8 | 2.8 | 37.6 | ||
Lauren (n = 496) | ||||||||
Intestinal | 222 | 44.8 | 4.3 | 39.9 | 0.716 | 4.8 | 49.3 | 0.598 |
Diffuse | 181 | 36.5 | 3.0 | 46.2 | 4.1 | 43.9 | ||
Mixed | 93 | 18.8 | 2.3 | 42.9 | 3.2 | 43.2 | ||
Grade | ||||||||
1 | 46 | 9.1 | NA | 62.2 | 0.025 | NA | 67.8 | 0.044 |
2 | 160 | 31.8 | 4.4 | 46.9 | 4.5 | 49.0 | ||
3 | 297 | 59.1 | 2.5 | 39.7 | 3.6 | 42.3 | ||
ILV | ||||||||
No | 149 | 29.6 | 6.9 | 62.4 | < 0.001 | 8.1 | 66.4 | < 0.001 |
Yes | 354 | 70.4 | 2.4 | 36.5 | 3.0 | 38.5 | ||
Antrum | ||||||||
Yes | 323 | 64.2 | 2.7 | 47.9 | 0.064 | 3.5 | 51.0 | 0.104 |
No | 180 | 35.8 | 4.5 | 38.8 | 5.1 | 40.8 | ||
Clinical stage | ||||||||
I | 64 | 12.7 | NA | 80.7 | < 0.001 | NA | 83.0 | < 0.001 |
II | 138 | 27.4 | 7.7 | 59.6 | 7.7 | 59.5 | ||
III | 301 | 59.8 | 1.9 | 29.3 | 2.3 | 33.2 | ||
Node involvement | ||||||||
No | 139 | 27.6 | 10.5 | 67.0 | < 0.001 | NA | 68.2 | < 0.001 |
Yes | 364 | 72.4 | 2.3 | 35.4 | 3.0 | 38.4 | ||
Recurrence | ||||||||
No | 322 | 64.0 | - | - | - | NA | 68.5 | < 0.001 |
Yes | 181 | 36.0 | - | - | 1.7 | 12.3 | ||
H. pylori HE (n = 415) | ||||||||
Absent | 184 | 44.3 | 3.8 | 42.9 | 0.252 | 4.5 | 46.0 | 0.637 |
Present | 231 | 55.7 | 7.3 | 48.3 | 5.3 | 51.2 | ||
H. pylori qPCR (n = 234) | ||||||||
Negative | 85 | 36.3 | 2.5 | 36.8 | 0.229 | 3.1 | 39.1 | 0.219 |
Positive | 149 | 63.7 | 3.8 | 38.3 | 4.0 | 39.7 | ||
dMMR (n = 479) | ||||||||
No | 269 | 65.6 | 4.3 | 45.8 | 0.396 | 4.7 | 47.9 | 0.158 |
Yes | 141 | 34.4 | 3.1 | 42.6 | - | 3.6 | 44.7 | - |
HER-2 status (n = 468) | ||||||||
Negative | 434 | 95.0 | 3.5 | 43.4 | 0.868 | 4.3 | 46.2 | 0.892 |
Positive | 23 | 5 | 3.1 | 39.8 | 3.3 | 39.3 | ||
IT TIL (n = 462) | ||||||||
< 10 | 186 | 40.3 | 2.7 | 41.8 | 0.763 | 3.7 | 43.6 | 0.395 |
≥ 10 | 276 | 59.7 | 3.7 | 44.0 | 4.5 | 47.1 | ||
ST TIL (n = 461) | ||||||||
< 30 | 258 | 55.9 | 2.6 | 41.5 | 0.458 | 3.8 | 45.0 | 0.853 |
≥ 30 | 203 | 44.0 | 3.8 | 44.8 | 4.4 | 46.3 | ||
IB TIL (n = 332) | ||||||||
< 70 | 178 | 53.6 | 3.3 | 46.0 | 0.991 | 4.4 | 47.8 | 0.660 |
≥ 70 | 154 | 46.4 | 4.4 | 46.4 | 4.9 | 49.4 | ||
IT CD3/HPF (n = 453) | ||||||||
< 58 | 126 | 27.8 | 2.4 | 34.3 | 0.028 | 2.9 | 36.5 | 0.021 |
≥ 58 | 327 | 72.2 | 4.4 | 47.0 | 5.4 | 50.5 | ||
IT CD8/ HPF (n = 443) | ||||||||
< 70 | 231 | 52.1 | 4.4 | 47.4 | 0.060 | 4.8 | 49.9 | 0.142 |
≥ 70 | 212 | 47.9 | 2.6 | 40.4 | 4.0 | 43.8 | ||
IT CD163/HPF (n = 205) | ||||||||
< 240 | 183 | 89.3 | 2.8 | 42.7 | 0.002 | 3.8 | 45.3 | 0.003 |
≥ 240 | 22 | 10.7 | 1.4 | 0.0 | 1.5 | 0.0 | ||
IT CD8/CD3 ratio (n = 432) | ||||||||
< 0.63 | 210 | 48.6 | 4.5 | 49.1 | <0.001 | 6.0 | 52.9 | 0.001 |
≥ 0.63 | 222 | 51.4 | 2.3 | 36.0 | 2.8 | 38.5 | ||
IT CD3/CD163 (n = 179) | ||||||||
< 8 | 137 | 76.5 | 22 | 33.9 | 0.004 | 2.6 | 36.6 | 0.002 |
≥ 8 | 42 | 23.5 | NA | 59.5 | NA | 64.3 | ||
ST CD3/HPF (n = 363) | ||||||||
< 95 | 180 | 49.6 | 2.6 | 36.6 | 0.014 | 2.9 | 38.7 | 0.003 |
≥ 95 | 183 | 50.4 | 5.2 | 50.7 | 7.0 | 54.6 | ||
ST CD8/HPF (n = 341) | ||||||||
< 68 | 216 | 63.3 | 3.8 | 43.5 | 0.578 | 4.0 | 45.0 | 0.382 |
≥ 68 | 125 | 36.7 | 3.6 | 43.0 | 4.5 | 47.5 | ||
ST CD8/CD3 ratio (n = 328) | ||||||||
< 1.2 | 277 | 84.5 | 4.3 | 45.9 | 0.005 | 4.6 | 49.1 | 0.002 |
≥ 1.2 | 51 | 15.5 | 1.9 | 26.1 | 2.0 | 26.6 |
- Citation: Castaneda CA, Castillo M, Bernabe LA, Sanchez J, Fassan M, Tello K, Wistuba II, Chavez Passiuri I, Ruiz E, Sanchez J, Barreda F, Valdivia D, Bazan Y, Abad-Licham M, Mengoa C, Fuentes H, Montenegro P, Poquioma E, Alatrista R, Flores CJ, Taxa L. Association between Helicobacter pylori infection, mismatch repair, HER2 and tumor-infiltrating lymphocytes in gastric cancer. World J Gastrointest Oncol 2024; 16(6): 2487-2503
- URL: https://www.wjgnet.com/1948-5204/full/v16/i6/2487.htm
- DOI: https://dx.doi.org/10.4251/wjgo.v16.i6.2487