Application of Fusobacterium nucleatum as a biomarker in gastrointestinal malignancies

doi:10.4251/wjgo.v16.i6.2271

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Jun 15, 2024; 16(6): 2271-2283
Published online Jun 15, 2024. doi: 10.4251/wjgo.v16.i6.2271

Table 2 The detection efficiency of Fusobacterium nucleatum in different gastrointestinal malignancies samples

Cancer	Samples	Risk assessment and detection rate of F. nucleatum	Method	Ref.
CRC	Tissue	72% (proximal) and 35% (distal)	qPCR	[84]
CRC	Tissue	38.8% (54/139)	ddPCR	[85]
CRC	Tissue	56.30% (18/32)	qPCR	[86]
CRC	Tissue	57.1% (8/14)	AP-PCR	[62]
CRC	Saliva	100% (14/14)	AP-PCR	[62]
CRC	Stool	Worse overall survival	16S rRNA sequencing	[10]
CRC	Tissue	Worse overall survival	16S rRNA sequencing	[10]
CRC	Tissue	50%	PCR	[87]
CRC	Stool	53.5%	PCR	[87]
GC	Tissue	26% (19/80)	qPCR	[88]
GC	Tissue	44% (40/91)	qPCR	[89]
GC	Tissue	28.75% (23/80)	qPCR	[66]
GC	Tissue	Worse overall survival	qPCR	[66]
EC	Tissue	69.4% (68/98)	qPCR	[71]
PC	Tissue	15.5% (13/84)	qRT-PCR	[73]
PC	Serum	52.4%	ELISA and qPCR	[75]

qPCR: Quantitative polymerase chain reaction; ddPCR: Droplet digtial polymerase chain reaction; AP-PCR: Arbitarily primed polymerase chain reaction; qRT-PCR: Quantitative reverse-transcription polymerase chain reaction; ELISA: Enzyme-linked immunosorbent assay; EC: Esophageal cancer; CRC: Colorectal cancer; PC: Pancreatic cancer.

Citation: Yu LC, Li YP, Xin YM, Mao M, Pan YX, Qu YX, Luo ZD, Zhang Y, Zhang X. Application of Fusobacterium nucleatum as a biomarker in gastrointestinal malignancies. World J Gastrointest Oncol 2024; 16(6): 2271-2283
URL: https://www.wjgnet.com/1948-5204/full/v16/i6/2271.htm
DOI: https://dx.doi.org/10.4251/wjgo.v16.i6.2271