MiRNA-145-5p inhibits gastric cancer progression via the serpin family E member 1- extracellular signal-regulated kinase-1/2 axis

Figure 8 Effect of serpin family E member 1 overexpression on gastric cancer cell proliferation and the signal-regulated kinase-1/2 pathway invitro and invivo. A: Expression of signal-regulated kinase-1/2 (ERK1/2) and p-ERK1/2 in SGC7901 co-transfected cells; B: Image of xenograft tumors at day 18 post-inoculation; C: Xenograft tumor growth, volume, and mass at day-18 post-inoculation. n = 5 mice per group; D: Ki67 expression in xenograft tumor tissue; Scale bar = 20 μm; E: E-cadherin, vimentin, serpin family E member 1, ERK1/2, and p-ERK1/2 expression in xenograft tumor tissues. ^aP < 0.05; ^bP < 0.01; ^cP < 0.001. SERPINE1: Serpin family E member 1; ERK1/2: Signal-regulated kinase-1/2.